Kinetic Modeling of Chemical Migration from Polyethylene Packaging Film: A Comparative Study of Regulatory Methods |
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| David J. Alcarde Jr., Elyson Keith P. Encarnacion, Anne C. Alcantara, Harold E. Armario, Winnie P. Alejandro, Agaseve F. Del Rosario, Rizel Marie S.M. Ting, Ellaine R. Dioso |
- Abstract:
- An awareness of chemical migration kinetics from the packaging to food is critical to determine consumer exposure and measure regulatory compliance. This paper analyzes the migration kinetics of the chemical residues of monolayer low density polyethylene (LDPE) package films under US 21 CFR and JETRO 2009 guidelines. LDPE film specimens were extracted with n-heptane at 21 °C for 30 minutes (US CFR) and 25 °C for 60 minutes (JETRO 2009). Migration data were modeled with zero-, first-, and second-order kinetic models. The results indicated poor correlation (R² < 0.1) for all the models, with second-order kinetics providing marginally better fits for low-concentration samples. High-concentration samples showed high variability, revealing complicated migration mechanisms outside classical kinetics. Residual analysis indicated uniform underprediction by zero- and first-order models. Generally, none of the conventional kinetic models sufficiently described migration behavior, which indicated shortcomings of traditional modeling strategies and the need for more appropriate modeling strategies in food safety evaluation.
- Download:
- IMEKO-TC8-11-24-2025-037.pdf
- DOI:
- 10.21014/tc24-2025.037
- Event details
- IMEKO TC:
- TC24
- Event name:
- IMEKO TC8, TC11 and TC24 Conference
- Title:
Joint conference of the TCs ‘Traceability in Metrology’ (IMEKO TC8), ‘Measurement in Testing, Inspection and Certification’ (IMEKO TC11), and ‘Chemical Measurements’ (IMEKO TC24).
- Place:
- Torino, ITALY
- Time:
- 14 September 2025 - 17 September 2025