Fluorescent Blood pCO2 Sensor with No Direct Blood–Fluorophore Contact: Real-Time Monitoring and Comparison with a Commercial Device |
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| Alessia Gallerani, Marco Muzzarelli, Alberto Ferrari, Stefano Cattini, Luigi Rovati |
- Abstract:
- Continuous monitoring of blood pCO₂ in extracorporeal circulation (ECC) would significantly support clinical decisions. Unfortunately, this is generally not possible during routine ECC. One of the aspects that limits the possibility of monitoring blood pCO₂ in real-time is biocompatibility. This study investigates the performance of a “prototype” fluorescent pCO₂ sensor (MS2), designed exploiting a blood-compatible gas-permeable membrane to isolate the sensing chemistry from the patient’s blood and the “off-label” use of a commercial optical CO₂ sensor, namely, the MCR-O1P1C1 by PreSens. Unlike the PreSens sensor, which requires direct contact between the sensing element and the blood, the gas-permeable membrane of the MS2 creates a measuring chamber that isolates the sensing chemistry from the patient’s blood. During a 6.5-hour test with bovine blood, both sensors demonstrated suitable accuracy, matching the reference hemogas analyzer. While at present the MCR-O1P1C1 sensor provides shorter response times, the MS2 sensor potentially offers superior safety and biocompatibility compared to sensors that require contact between the sensing element and the patient's blood. These results position the MS2 as a promising solution for real-time, in-line blood gas monitoring in ECC procedures.
- Download:
- IMEKO-TC2-2025-006.pdf
- DOI:
- 10.21014/tc2-2025.006
- Event details
- IMEKO TC:
- TC2
- Event name:
- IMEKO TC2 PhotoMet 2025
- Title:
2025 IMEKO TC2 International Symposium on Modern Photonic Metrology
PhotoMet 2025 - Shaping the Future of Photonic Metrology
- Place:
- Modena, ITALY
- Time:
- 01 September 2025 - 03 September 2025